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Accueil > À noter > Séminaires > Friday 16 February 2018, 10h30. Charles SFEIR, Université de Pittsburgh. Amphi. Jacques PAILLARD, Faculté des Sciences du Sport, Campus de Luminy (Marseille). Resorbable Metals – From Device Development, to Cell Signaling and Clinical Applications.

Friday 16 February 2018, 10h30. Charles SFEIR, Université de Pittsburgh. Amphi. Jacques PAILLARD, Faculté des Sciences du Sport, Campus de Luminy (Marseille). Resorbable Metals – From Device Development, to Cell Signaling and Clinical Applications.

Invité par Imad ABOUT

Mise à jour : 29 janvier

Due to their unique combination of degradation and strength, magnesium based resorbable metal alloys are being explored for many clinical applications such as bone repair and regeneration. Interestingly, the degradation behaviour of these materials is highly sensitive to the local environment, including ion concentrations, fluid flow rate, and pH. In addition, the released Mg ion during device degradation seems to be enhancing bone healing and regeneration. suggesting that magnesium fixation devices may be able to enhance fracture healing. Interestingly, ongoing assessments of a faster degrading magnesium alloy have revealed a dichotomy in the associated biological response. We have observed both regions of bone loss and bone formation around the degrading devices. These in vivo results have provided the rationale to launch a series of mechanistic Mg signalling studies to elucidate the signalling mechanism(s) of Mg on bone and also to develop novel devices for dental application in the field of bone augmentation and regeneration.

Post-scriptum :

Biography :
Dr. Charles Sfeir is the Associate Dean for Research, the Director of the Center for Craniofacial Regeneration and the Chairman of the department of Periodontics and Preventive Dentistry at the University of Pittsburgh. Dr. Sfeir has secondary appointments in the departments of Oral Biology, Bioengineering, the Clinical and Translational Science Institute and the McGowan Institute for Regenerative Medicine. He received a DDS from the Université Louis Pasteur in Strasbourg, France. He also earned an MS in Periodontology, a DDS and a PhD in Molecular Biology and Biochemistry from Northwestern University in Chicago, Illinois.

Dr. Sfeir’s research encompasses the following areas :
Bone and dentin tissue engineering, utilizing biomaterials and cellular strategies to regenerate mineralized tissues
Biomineralization, post-translational modifications of non-collagenous proteins in bone and dentin
Modulation of the immune system to develop therapies for periodontal disease
Biodegradable metals, developing load bearing bone fixation devices
Pulp tissue regeneration, developing strategies to achieve better endodontic therapies using biomaterials versus cellular approaches
Pre-clinical testing devices for FDA approval